Professor Dr. Ahmed Mahmoud Sultan, a lecturer at the College of Pharmacy, was chosen as a member of the Master’s thesis discussion at the College of Medicine at Al-Qadisiyah University, which discussed the effect of sitagliptin as an additional treatment for metformin in type 2 diabetes patients who suffer from left ventricular diastolic muscle failure and its role in epigenetic modification of non-coding ribonucleic acid The Department of Clinical Medicine at the College of Medicine at Al-Qadisiyah University discussed the master’s thesis entitled (The effect of sitagliptin as an additional treatment for metformin in type 2 diabetes patients who suffer from left ventricular diastolic muscle failure and its role in epigenetic modification (non-coding ribonucleic acid)) for the student Aswar Jawad Abdul-Kazem and under the supervision of Prof. Dr. Basem Rahim Muhammad The thesis aimed to study the potential effect of sitagliptin on epigenetic regulation and the inflammatory process, and to clarify the role of sitagliptin on left ventricular diastolic muscle failure in type 2 diabetes patients
\nThe most important conclusions We noticed a decrease Significantly increased levels of MALAT1 and MicroRNA150-5p, which are associated with increased cardiomyocyte apoptosis and enhanced clinical response to sitagliptin in diabetic patients taking sitagliptin added to metformin therapy. However, our analysis revealed a decrease in galectin concentrations. Key recommendations Future research should focus on investigating gene-environment relationships, as well as studying genotype patterns. To strengthen the results of this study, longer follow-up with clinical outcomes, biomarkers, and additional non-coding RNAs are needed in Iraqi diabetic patients<\/p>\n","protected":false},"excerpt":{"rendered":"